Casein Kinase

Kinase

Casein Kinase

Casein Kinase Isoform Specific Products:

Casein Kinase Related Products (170)
Antibodies (5)
Casein Kinase Isoform Comparison

By Effects:	Ligand (1) Inhibitors (151) Degraders (5) Antagonist (1) Activator (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10108

LY294002	Inhibitor	99.95%
LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively. LY294002 also inhibits CK2 with an IC₅₀ of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4?μM. LY294002 is an apoptosis activator.

HY-50855

Silmitasertib	Inhibitor	99.94%
Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC₅₀ values of 1 nM against CK2α and CK2α'.

HY-13912

IWP-2	Inhibitor	99.93%
IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC₅₀ of 40 nM for the gatekeeper mutant ^M82FCK1δ.

HY-14393

Emodin	Inhibitor	99.25%
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice.

HY-B0183

Ellagic acid	Inhibitor	99.46%
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-134567A

Ac-VDVAD-CHO TFA	Inhibitor
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor (IC₅₀: 46 and 15 nM).

HY-169690

Casein kinase 1δ-IN-20	Inhibitor
Casein kinase 1δ-IN-20 (compound 427) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-20 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.

HY-171298

CK1δ-IN-10	Inhibitor
CK1δ-IN-10 (Compound 85) is the inhibitor for casein kinase 1 that inhibits CK1δ (CSNKID) with IC₅₀ of 0.255 μM.

HY-10324

D4476	Inhibitor	99.94%
D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC₅₀ value of 0.3 μM in vitro.

HY-15490

PF-670462 dihydrochloride	Inhibitor	99.96%
PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC₅₀s of 7.7 nM and 14 nM, respectively.

HY-50855B

Silmitasertib sodium salt	Inhibitor	99.92%
Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC₅₀ values of 1 nM against CK2α and CK2α'.

HY-14394

TBB	Inhibitor	98.83%
TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC₅₀ of 0.15 μM for rat liver CK2.

HY-12279

Umbralisib	Inhibitor	98.94%
Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC₅₀ of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach.

HY-145322

TMX-4116	Inhibitor	99.76%
TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC₅₀s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.

HY-123954

BTX-A51	Inhibitor	98.58%
BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities.

HY-145319

FPFT-2216	Inhibitor	99.75%
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease.

HY-100011

SR-3029	Inhibitor	99.73%
SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC₅₀s of 44 nM and 260 nM, respectively, and K_is of 97 nM for both kinases.

HY-12470

PF-4800567	Inhibitor	99.69%
PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC₅₀ of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC₅₀, 711 nM).

HY-160444

SJ3149	Degrader	99.48%
SJ3149 is a selective and potent molecular glue degrader of CK1α protein with broad antiproliferative activity. SJ3149 can be used in cancer research.

HY-147141

HS-276	Inhibitor	98.59%
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research.

Silmitasertib		CK2α, IC₅₀: 1 nM CK2α', IC₅₀: 1 nM	99.94%
IWP-2	CK1δ, IC₅₀: 40 nM		99.93%
Emodin		CK2α Wild-type, IC₅₀: 5.9 μM (at ATP concentration is 50 μM) CK2α Wild-type, IC₅₀: 1.4 μM (at ATP concentration is 10 μM)	99.25%
Ellagic acid		CK2, IC₅₀: 40 nM	99.46%
CK1δ-IN-10	CK1δ, IC₅₀: 0.255 μM
D4476	CK1, IC₅₀: 0.3 μM		99.94%
PF-670462 dihydrochloride	CKIδ, IC₅₀: 14 nM		99.96%
Silmitasertib sodium salt		CK2α, IC₅₀: 1 nM CK2α', IC₅₀: 1 nM	99.92%
TBB		CK2, IC₅₀: 0.15 μM (Human CK2)	98.83%
TMX-4116	CK1α		99.76%
BTX-A51	CKIα		98.58%
FPFT-2216	CK1α		99.75%
SR-3029	CKIδ, IC₅₀: 44 nM		99.73%
PF-4800567	CKIδ, IC₅₀: 711 nM		99.69%
DMAT		CK2, IC₅₀: 0.13 μM (Human CK2)	98.09%
SGC-CK2-1		CK2α, IC₅₀: 36 nM CK2α', IC₅₀: 16 nM	99.67%
IC261	CKIδ, IC₅₀: 1 μM CkIα1, IC₅₀: 16 μM		99.54%
AMG-548 dihydrochloride	CK1		99.91%
TAK-715	CK1δ CK1ε		99.76%
PF-5006739	CK1δ, IC₅₀: 3.9 nM		99.56%
CKI-7 free base	CK1, IC₅₀: 6 μM CK1, Ki: 8.5 μM		99.80%
BioE-1115		CK2α, IC₅₀: 10 μM	99.56%
CK2/ERK8-IN-1		CK2, IC₅₀: 0.5 μM CK2, Ki: 0.25 μM	≥99.0%
TTP 22		CK2, IC₅₀: 100 nM	98.40%
LY294002 hydrochloride		CK2, IC₅₀: 0.098 μM CK2α2, IC₅₀: 3.869 μM	99.93%
Hematein		CKII, IC₅₀: 0.74 μM
CK1-IN-1	CKIδ, IC₅₀: 15 nM		99.35%
Casein Kinase inhibitor A86	CKIα		99.26%
TA-01	CKIδ, IC₅₀: 6.8 nM		99.86%
MU1742	CKIδ		99.74%
Casein Kinase 2 Substrate Peptide		CK2	98.47%
CK2 inhibitor 2		CK2, IC₅₀: 0.66 nM	98.51%
NCC007	CKIα, IC₅₀: 1.8 μM CKIδ, IC₅₀: 3.6 μM		99.73%
LH846	CKIδ, IC₅₀: 290 nM CKIα, IC₅₀: 2.5 μM		98.18%
TMX-4113	CK1α		99.08%
TBCA		CK2, IC₅₀: 110 nM CK2, Ki: 77 nM	99.45%
Longdaysin	CKIα, IC₅₀: 5.6 μM CKIδ, IC₅₀: 8.8 μM		99.83%
ON 108600		CK2α2, IC₅₀: 0.005 μM CK2α1, IC₅₀: 0.05 μM	99.73%
MRT00033659	CKIδ, IC₅₀: 0.9 μM		99.77%
PI-828		CK2, IC₅₀: 149 nM CK2α2, IC₅₀: 1.127 μM	99.62%
CK1-IN-2	CKIα, IC₅₀: 123 nM		99.54%
BRD4/CK2-IN-1		CK2, IC₅₀: 230 nM	98.62%
AMG-548	CK1		≥99.0%
Quinalizarin		CK2, Ki: ~50 nM CK2, IC₅₀: 110 nM
SRPIN803		CK2, IC₅₀: 203 nM	99.17%
(R)-DRF053 dihydrochloride	CK1, IC₅₀: 14 nM		99.30%
A-3 hydrochloride	CK1, Ki: 80 μM	CK2, Ki: 5.1 μM	99.75%
Casein kinase 1δ-IN-1	CKIδ		99.91%
Casein kinase 1δ-IN-9	CK1δ		≥98.0%
IQA		CK2
Casein Kinase II Receptor Peptide		CK2, Km: 500 μM
CKI-7	CK1, IC₅₀: 6 μM CK1, Ki: 8.5 μM
QXG-6442	CK1α, DC₅₀: 5.7 nM
Casein kinase 1δ-IN-27	CK1ε, IC₅₀: 9.41 nM CK1δ, IC₅₀: 16.5 nM CK1α, IC₅₀: 22 nM
CK2-IN-3		CK2α, IC₅₀: 1.51 μM CK2α', IC₅₀: 7.64 μM
Ellagic acid (hydrate)		CK2, Ki: 20 nM CK2, IC₅₀: 40 nM
Casein kinase 1δ-IN-29	CKIδ, IC₅₀: 0.005 μM CK1ε, IC₅₀: 0.447 μM
Casein kinase 1δ-IN-4	CK1δ		≥98.0%
SR-4133	CK1ε, IC₅₀: 58 nM CK1δ, IC₅₀: 10 μM
CK2-IN-13		CK2, IC₅₀: 5.8 nM
Casein kinase 1δ-IN-3	CKIδ, pIC₅₀: 6.5376 M		99.93%
PIM-1/CK2-IN-2		CK2
Casein kinase 1δ-IN-10	CK1δ
MGD-28	CK1α, DC₅₀: 7.8 nM
TID43		CK2, IC₅₀: 0.3 μM
CK1-IN-3	CK1δ, IC₅₀: 2.22 μM		99.00%
CK2/PIM1-IN-1		CK2, IC₅₀: 3.787 μM
CK1-IN-4	CKIδ, IC₅₀: 2.74 μM
Casein kinase 1δ-IN-16	CKIδ
AMG-548 hydrochloride	CK1
SR-1277	CKIδ, IC₅₀: 49 nM
CK1δ-IN-3	CKIδ
Emodin (Standard)		CK2α Wild-type
CK2 inhibitor 4		CK2, IC₅₀: 3.8 μM
Casein kinase 1δ-IN-28	CK1ε, IC₅₀: 14.6 nM
EGFR-IN-57		CK2α, IC₅₀: 0.171 μM
Casein kinase 1δ-IN-15	CK1δ, IC₅₀: 0.045 μM
Multi-kinase-IN-6		CK2, IC₅₀: 0.09 μM
Casein kinase 1δ-IN-5	CK1δ, IC₅₀: 47 nM
Casein kinase 1δ-IN-17	CKIδ
Casein kinase 1δ-IN-18	CKIδ
HDAC/CK2-IN-1		CK2, IC₅₀: 3.67 μM
CK1δ-IN-9	CKIδ, IC₅₀: 1.4 nM
TMCB		CK2α, Ki: 83 nM CK2α', Ki: 21 nM
CK2 inhibitor 3		CK2, IC₅₀: 280 nM
Casein kinase 1δ-IN-31	CK1δ, IC₅₀: 17 nM CK1α, IC₅₀: 196 nM
p38α inhibitor 8	CK1δ, IC₅₀: 0.202 μM
4,5,6,7-Tetrabromo-1H-benzimidazole		CK2
CK2-IN-14		CK2, IC₅₀: 0.66 nM
CK2-IN-12		CK2, IC₅₀: 0.8 μM
WAY-606344	CK1δ
CSNK2-IN-2		CK2

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Casein Kinase

Casein Kinase

Casein Kinase Isoform Specific Products:

Casein Kinase Isoform Specific Products:

Casein Kinase Related Products (170)

Antibodies (5)

Casein Kinase Isoform Comparison

Casein Kinase Related Products (170):